Now showing items 1-17 of 17

    • Domenech Lira, Raúl; Macho Fisher, Pilar (2008)
      Aging produces its own cardiovascular changes, mainly remodelling of arteries, heart and the microcirculation. These progressive changes, detected since adolescence, represent a major risk factor for the development of ...
    • Domenech Lira, Raúl; Goich, Jaime (1976)
      The effect of tachycardia on the distribution of coronary blood flow was studied in the dog heart using the radioactive microsphere technique. Increasing heart rate from 1.7 to 3.0 Hz produced an increment of flow to the ...
    • Domenech Lira, Raúl; Goich, Jaime (Oxford University Press, 1976)
      AUTHORS' SYNOPSIS: The effect of tachycardia on the distribution of coronary blood flow was studied in the dog heart using the radioactive microsphere technique. Increasing heart rate from 1.7 to 3.0 Hz produced an increment ...
    • Domenech Lira, Raúl; Sánchez, Gina; Donoso Laurent, Paulina; Parra Morales, Víctor; Macho Fisher, Pilar (ACADEMIC PRESS LTD ELSEVIER SCIENCE LTD, 2003-12)
      We have previously demonstrated that brief episodes of tachycardia prior to a prolonged occlusion of a coronary artery, followed by reperfusion, substantially reduce the infarct size. Adenosine receptors and mitochondrial ...
    • Sánchez, Gina; Escobar, Matías; Pedrozo Cibils, Zully; Macho Fisher, Pilar; Domenech Lira, Raúl; Härtel, Steffen; Hidalgo Tapia, María Cecilia; Donoso Laurent, Paulina (2008)
      Aim: Our objective was to investigate in cardiac muscle the contribution of NADPH oxidase to (a) ryanodine receptor-2 (RyR2) S-glutathionylation and (b) the preconditioning effects of exercise and tachycardia on infarct ...
    • Domenech Lira, Raúl; Macho Fisher, Pilar; Schwarze, Hermann; Sánchez, Gina (2002)
      Objective: We tested the hypothesis that exercise induces myocardial preconditioning in dogs. Methods: We instrumented dogs with a snare on the anterior descending coronary artery and catheters in the root of the aorta, ...
    • Parra, Víctor M.; Macho Fisher, Pilar; Sánchez, Gina; Donoso Laurent, Paulina; Domenech Lira, Raúl (Lippincott Williams and Wilkins, 2015)
      We showed that exercise induces early and late myocardial preconditioning in dogs and that these effects are mediated through nicotinamide adenine dinucleotide phosphate reduced form (NADPH) oxidase activation. As the ...
    • Parra, Víctor M.; Macho Fisher, Pilar; Domenech Lira, Raúl (2010)
      We previously showed that exercise induces myocardial preconditioning in dogs and that early preconditioning is mediated through mitochondrial adenosine triphosphate-sensitive potassium channels. We decided to study if ...
    • Domenech Lira, Raúl; De La Prida, (1975)
      The mechanical effects of heart contraction on coronary flow were studied in the dog heart by implanting vessels in the subendocardial and subepicardial layers of the left ventricular wall and perfusing them independently ...
    • Domenech Lira, Raúl; De La Prida, Julio M. (Oxford University Press, 1975)
      AUTHORS' SYNOPSIS: The mechanical effects of heart contraction on coronary flow were studied in the dog heart by implanting vessels in the subendocardial and subepicardial layers of the left ventricular wall and perfusing ...
    • Domenech Lira, Raúl; Macho Fisher, Pilar (1998)
      The reduction of infarct size produced by brief ischemic episodes prior to a sustained occlusion of a coronary artery, called ischemic preconditioning, is a well known phenomenon that occurs in several species, but its ...
    • Sánchez, Gina; Fernández, Carolina; Montecinos, Luis; Domenech Lira, Raúl; Donoso Laurent, Paulina (2011)
      Cardioprotection by preconditioning is a central issue of current research on heart function. Several reports indicate that preventing the assembly and opening of the mitochondrial permeability transition pore (mPTP) ...
    • Macho Fisher, Pilar; Domenech Lira, Raúl; Penna Varela, Mario (1995)
      The metabolites that mediate coronary reactive hyperemia have not been definitely identified. Although adenosine and endothelium derived substances seem to be involved, their relative contributions have not been defined ...
    • Sánchez, Gina; Pedrozo Cibils, Zully; Domenech Lira, Raúl; Hidalgo Tapia, María Cecilia; Donoso Laurent, Paulina (ACADEMIC PRESS LTD ELSEVIER SCIENCE LTD, 2005-12)
      We have shown previously that electrically induced tachycardia effectively produces myocardial preconditioning. Among other effects, tachycardia increases calcium release rates in microsomal fractions enriched in sarcoplasmic ...
    • Domenech Lira, Raúl (Oxford University Press, 1974)
      Total and regional coronary blood flow was measured with radioactive microspheres before and early after the occlusion of the anterior descending coronary artery. A radial gradient of flow was found in the ' infarcted' ...
    • Domenech Lira, Raúl; Ayuy, Antonio H. (1974)
      Total and regional coronary blood flow were measured with radioactive microspheres before and during acute right ventricular pressure overload. Coronary flow to the left ventricular wall decreased and coronary vascular ...
    • Domenech Lira, Raúl; Ayuy, Antonio H. (Oxford University Press, 1974)
      AUTHORS' SYNOPSIS: Total and regional coronary blood flow were measured with radioactive microspheres before and during acute right ventricular pressure overload. Coronary flow to the left ventricular wall decreased and ...